diff --git a/src/Php/CompilerBase.php b/src/Php/CompilerBase.php
index 8477d176..28627aa7 100644
--- a/src/Php/CompilerBase.php
+++ b/src/Php/CompilerBase.php
@@ -3197,7 +3197,11 @@ class CompilerBase extends \PhpAot\Core\Translator
     {
         $vars = $expr->vars;
         if (count($vars) > 1) {
-            $this->fatalError($expr, 'Cannot check multiple variables with isset');
+            $list = [];
+            foreach ($vars as $var) {
+                $list[] = $this->parseVarCheckExpr($var, 'isset');
+            }
+            return '(' . implode(' && ', $list) . ')';
         }
         return $this->parseVarCheckExpr($vars[0], 'isset');
     }
diff --git a/tests/aot/isset-002.phpt b/tests/aot/isset-002.phpt
new file mode 100644
index 00000000..795367f1
--- /dev/null
+++ b/tests/aot/isset-002.phpt
@@ -0,0 +1,17 @@
+--TEST--
+isset 002
+--FILE--
+<?php
+$array1 = [ 2000, 0, ];
+$array2 = [ 2022, null, ];
+
+var_dump(isset($array1[0], $array2[0]));
+var_dump(isset($array1[1], $array2[1]));
+var_dump(isset($array1[1], $array2[0]));
+var_dump(isset($array1[0], $array2[1]));
+?>
+--EXPECT--
+bool(true)
+bool(false)
+bool(true)
+bool(false)